Microscopic analysis revealed the formation of highly dynamic actin filaments around the spindle poles which precede and guide the growth of spindle microtubules. In the absence of FAM110A ...

At the other extreme, chromosomes with multiple centromeres are subject to fragmentation if the centromeres become attached to opposite spindle poles by way of their kinetochores. After nearly two ...

The length of these kinetochore-attached microtubules then decreases during mitosis, pulling sister chromatids to opposite poles of the spindle. Other spindle fibers do not attach to chromosomes ...