Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators of liver fibrosis—have a commanding ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Hepatic stellate cells (HSCs), the liver's primary mesenchymal cells, play a critical role in both regeneration and fibrosis. Despite their importance, it remains unclear whether specific genes in ...

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function. Researchers from Columbia University and ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...