Malfunction of the p53 pathway is an almost universal hallmark of human tumours. [1,2] Somatic mutation of TP53 that results in the absence or dysfunction of p53 is one of the most common ...

deriving elephant iPSCs proved challenging because these animals have a complex gene pathway not found in other species. The researchers overcame this by suppressing core genes called TP53 that ...

Defects in the DNA damage sensors, particularly in the ataxia telengiectasia mutated (ATM)/TP53 pathways, confer resistance to standard chemotherapic agents used in CLL [4] that inflict DNA damage ...