tacrolimus 7 mg twice per day, and mycophenolate mofetil 750 mg twice per day. Mild renal insufficiency, with a serum creatinine level of 133 µmol/l (1.5 mg/dl), occurred 4-5 months after ...

The other two were withdrawn from tacrolimus on day 130. One monkey had an increasing creatinine and a biopsy consistent with tacrolimus nephrotoxicity at the time of tacrolimus withdrawal.

Obtain tacrolimus whole blood concentrations (see full labeling), serum creatinine, and serum potassium periodically. Avoid in congenital long QT syndrome. CHF, bradyarrhythmias, concomitant ...