Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid ...

Transmembrane signaling systems include membrane-bound cell surface receptors and molecules called ligands that bind to these receptors. In its most general use, "ligand" is a term for something ...

Low levels of soluble neuropilin-1 are associated with depression in patients with newly diagnosed type 2 diabetes, ...

GSK's clinical-stage pipeline is currently focused on oncology, respiratory, immunology and inflammation, and infectious ...

Advances in protein structure prediction tools, such as AlphaFold and ColabFold, have enabled the modeling of complex ...

Transmembrane proteins involve various physiological functions, including protein ligation, recognition, transport, anchoring, and transduction. Several diseases are connected with abnormalities ...

show that a transmembrane motif performs the biosynthetic quality control during subunit assembly of functional AChR complexes (Nat Neurosci 2002, DOI:10.1038/nn918). Wang et al. transfected COS cells ...