The study of protein–protein interactions that involve integral membrane proteins has been thwarted by the difficulty of biochemical approaches and the unsuitability of genetic two-hybrid ...

Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane.

"Drug interactions with proteins in the membrane do not adhere to the same norms or conventions as soluble drugs, so these types of models ... GPCRs are integral membrane proteins that span ...