Epidermal growth factor receptor contains an extracellular ... Mutations activating the RAS-RAF signaling pathway will confer resistance to EGFR inhibitors. [12] Two pathways thought to be ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

EGF receptor (EGFR) and HER2 are two members of the ErbB/HER-family of tyrosine-kinase receptors that are frequently altered in breast cancer and several other malignancies, which inspired the ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...