"Back-to-back" storms driving "once in a generation flooding" threaten millions of Americans with a "catastrophic risk to life" weather event. A "rare and dangerous" union of deadly atmospheric conditions spanning thousands of miles will this week hit almost 20 US states.

More than 180 million people could see severe weather through midweek, with more than two dozen states at risk, according to AccuWeather.

Storms will slowly spread east through the afternoon. While Sunday may not be a complete washout for everyone, your plans are likely to be disrupted by rainfall. Especially if you'll be outdoors, stay weather aware with the threat for isolated strong to severe storms.

One person was killed and 10 others were injured, one critically, as tornadoes and severe weather struck the Midwest and mid-South Wednesday, destroying buildings, toppling semis and train cars, and tearing down trees, officials said.

KENTUCKY, USA — Severe weather is once again taking aim at Kentucky and southern Indiana on Wednesday. Portions of western Kentucky are under a high risk for severe weather while the rest of the state is under a moderate risk, including Louisville, or an enhanced risk.

Repeated waves of thunderstorms will pose risks to lives and property through the weekend in the same areas that were blasted by deadly storms on Wednesday and Wednesday night.

"This is a rare, high-impact, and potentially devastating event," The National Weather Service wrote on X. "Heavy rainfall will likely lead to widespread river, flash, and areal flooding that could cause severe disruptions especially along and north of I-40."

A life-threatening outbreak of long-lived and strong tornadoes is expected today in parts of the central and eastern US from a powerful, wide-reaching spring storm.

At least five people died in Tennessee and one each in Missouri and Indiana as severe thunderstorms move through the central part of the nation.

At least seven people have died as thunderstorms and tornadoes ravaged several US states, with more severe weather expected. Fatalities were reported in Tennessee, Indiana, and Missouri as the storms hit on Wednesday and Thursday.