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New study challenges longstanding assumption about the cause of the genome's most common mutation
The mutation in question—in which cytosine ... result of a spontaneous chemical reaction with water. This reaction, deamination, is about twice as likely to happen when a cytosine is chemically ...
Nature2y
Mutation detection by electrocatalysis at DNA-modified electrodes
Detection of mutations and damaged DNA bases is important ... and physical agents present in the cell 24. For example, the deamination of cytosine gives rise to a CG to AT transition.
Nanowerk8mon
Adenine (A): The Building Block of Life
Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of ...