Recently developed major histocompatibility complex (MHC) multimer technologies allow visualization and isolation of antigen-specific T cells. However, functional analysis and in vivo transfer of ...

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for ...

"T cells have been thought to discriminate between small fragments of protein derived from self and non-self proteins presented on the major histocompatibility complex II (MHC-II), and 'trained ...

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for ...

He assembled volunteers, 49 women and 44 men selected for their variety of MHC gene types. He gave the men clean T-shirts to wear for two nights and then return to the scientists. In the ...

Researchers sought to determine whether the CAR-T therapy volamcabtagene durzigedleucel (CTX130) would be effective in patients with T-cell lymphoma.

The patrolling T cells constantly scan host tissues to eliminate infected ... (2023) Facile repurposing of peptide-MHC restricted antibodies for cancer immunotherapy. Nat. Biotechnol. 41, 932-943.