The researchers found that two key neuron populations, namely Th + (tyrosine hydroxylase-expressing) and Gcg + (glucagon-like peptide 1-expressing) neurons encoded different aspects of food intake.

The NCLs (neuronal ceroid lipofuscinosis ... to a downstream position for CLN2 protein in the hypothetical metabolic pathway. Interestingly, correction of defects in CLN3-deficient cells by ...

elegans with neuronal mitochondrial ... β Dauer signaling pathway. It highlights the critical role of TGF-β in systemically ...

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, ...

The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have ...

The researchers use multimodal and molecular imaging to describe intact but also abnormal metabolic regulation. Once neuronal signaling pathways of the metabolism are completely understood both in ...

Neuronal pathway finding is crucial for structured cellular organization and development of neural circuits within the nervous system. Neuronal pathway finding within the visual system has been ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

All metabolic pathways have to be regulated and controlled to stop the build-up of an end product that isn’t needed. The cell can control a metabolic pathway by the presence or absence of a ...

Metabolic pathways can be reversible or irreversible. Almost all pathways are reversible. If a specific enzyme or substrate isn’t available in a pathway then sometimes an end product can still ...

While previous research has highlighted the key role of the cNTS in food intake regulation, the unique contribution of the different neuron subtypes within this brainstem region and the mechanisms ...