Cell cycle re-entry of senescent breast cancer cells after CDK4/6 inhibition (CDK4/6i) constitutes a major source of disease ...

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...

For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in ...

a lysosome inhibitor might help here and ideally, the functional mitophagy assays should be repeated in autophagy KOs. The link to tumorigenesis and cancer survival is very interesting but it is not ...

In summary, CMTM4 prevents EGFR from lysosomal degradation, which further amplifies EGFR signaling and activation of the Akt/mTOR/NF-κB pathways to promote tumor growth. To mimic the natural ...

Completed autophagosome fuses with the lysosome to form the autolysosome ... AMPK, AMP-activated protein kinase; ATG, autophagy-related proteins; BafA1, bafilomycin A1; BECN1, Beclin-1; BCL-2, B Cell ...

Proton pump inhibitors (PPI) use is associated with increased risk of enteric infections, in particular with a 65% increase in incidence of Clostridium difficile infection. PPI is one of the most ...

7 International Research Fellow of Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan (Standard)), Tokyo, Japan Correspondence to Dr Shinji Saitoh, Department ...