This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...

as they inhibited Fas antibody-induced release of cytochrome c and activated caspase 9, and caspase 3 or caspase 7, but not caspase 8 (Ref. 58). It has been proposed that the suppression of Fas ...

Platycodin D (PD) is a triterpene saponin extracted from the root of Platycodon grandiflorum. It has been reported to exhibit multiple pharmacological and biological properties. There is substantial ...

Immunohistochemistry: A Ki-67 rat anti-mouse antibody was obtained from Dako. A monoclonal mouse against αSMA (M0851) was from DAKO, and a monoclonal rabbit anti-cleaved caspase-3 (Asp175; 5A1E) was ...

Antibody against cytochrome C oxidase subunit 4 isoform 1 ... over night at 4°C with primary antibodies against Bax (1:1000), Bcl-2 (1:1000), cleaved caspase-3 (1:1000), caspase-3 (1:2000), cleaved ...

However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function. Neural lamination is a common feature of the central nervous ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

In contrast, combined treatment with cabozantinib and the checkpoint inhibitor anti-PD-L1 antibody did not provide any additional therapeutic benefit in the four mouse HCC models tested. Conclusion ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

Correspondence to Professor Gabriela Riemekasten, Department of Rheumatology, University Hospital Schleswig-Holstein—Campus Lübeck, Ratzeburger Allee 160, Lübeck 23538, Germany; ...