Scientists develop new natural killer cell strategy to target HIV
Researchers at The Wistar Institute's HIV Cure and Viral Diseases Center have successfully identified a new approach using ...
eLife8d
Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...
thorax.bmj13d
Inflammation in preschool cystic fibrosis is of mixed phenotype, extends beyond the lung and is differentially modified by CFTR modulators
Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...
gut.bmj11d
Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system
Dissociated cells were incubated with Zombie Aqua Viability (Biolegend, San Diego, California, USA) followed by blocking with 5% rat serum and mouse anti-CD16/CD32 (eBioscience, San Diego, California, ...
Frontiers15d
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
Cells were counted using a Sysmex hematology analyzer (Sysmex). Cells were incubated with Fc-blocking antibodies (CD16/32, clone: 93, BD) prior to staining with fluorescently labeled antibodies. For ...
Cancer Research11d
The FcγRIIIA (CD16) L48-H/R Polymorphism Enhances NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity by Promoting Serial Killing
1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
gut.bmj5d
Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease
Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...
The New England Journal of Medicine17d
Hemophagocytic Lymphohistiocytosis
Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...
Nature18d
Autoimmune disease: why and where it occurs
Autoimmune disease is controlled by host genes and the environment. Both can increase susceptibility to autoimmunity by affecting the overall reactivity and quality of the cells of the immune system.