The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

First, a so-called initiator protein unwinds a short stretch of the DNA double helix. Then, a protein known as helicase attaches to and breaks apart the hydrogen bonds between the bases on the DNA ...

when the leading-strand polymerase pauses the rate of the DNA helicase unwinding the parental template is reduced to about 15% of the normal rate. Once the leading-strand polymerase resumes DNA ...

The small molecule works by inhibiting ALC1 (chromodomain-helicase-DNA-binding protein 1-like), a chromatin remodeller and DNA helicase also involved in DNA repair. In what Schomburg terms a ...

in controlling fork progression and origin activation by inhibiting the activities of the replicative DNA helicase, CMG (Cdc45-MCM-GINS), and the cell cycle-regulated protein kinase, DDK ...

A search for Npw38-interacting molecules revealed that Npw38 can interact with NpwBP, DNA helicase, RNA helicase, RNA, and single-stranded DNA to form a nuclear protein complex which may be involved ...

First, it assists another protein, topoisomerase IIα (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled threads into a simpler ...

First, it assists another protein, topoisomerase IIα (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled threads into a simpler ...