The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

First, it assists another protein, topoisomerase IIα (TOP2A), in untangling the DNA threads. Second, it works with a protein called BLM helicase to convert tangled threads into a simpler ...

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While Leah, who was born in 2006, won’t meet the same milestones as other young people her age - such as moving out or going ...

To our knowledge, there are no existing investigations employing a separation protocol resembling the helicase dissociation process of DNA. Helicases break hydrogen bridges in a helicoidal-sequence ...

The 18-year-old's mom and sister work hard to give her the life she deserves as she battles a rare genetic condition ...

Each ATPase contains a QLQ protein interaction domain (QLQ, blue), a helicase SANT-associated domain (HSA ... (orange), and a regulatory factor binding to the X-box (RFX, purple) DNA binding domain.

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...

DNA from a minimum of 1 e-6 cells from each fraction was isolated ... Derepression of C-pro transcription in sir2 causes RNA PolII to push the Mcm helicase complex from its normal location (arrow ...