Cancer cells have special adaptation mechanisms that allow them to proliferate despite changes in their genetic makeup. Researchers at RPTU University Kaiserslautern-Landau, Rhineland-Palatinate, ...

This study presents important findings on the activity of two compounds ... Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability ...

A new study suggests that diets high in fast food, processed red meat, and soda but low in fruits and vegetables may be ...

This manuscript reports valuable findings on the role of the Srs2 protein in turning off the DNA damage signaling ... Mec1 and peaks after Mec1 activity reaches maximal levels. Based on these data, we ...

For instance, in evaluating the epigenetic regulatory effects of xenon (Xe) in a rat model of stroke ... DNMT3b mutations impair de novo DNA methylation. ZBTB24, CDCA7, and HELLS mutations lead to ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Witness the fascinating world of DNA replication brought to life through magnetic ball experiments. These magnetic games use a unique visual approach to demonstrate how the building blocks of life ...

DNA polymerases carry out crucial functions in many DNA metabolic processes. Polymerases catalyse the addition, using a template, of complementary nucleotides to the 3′ end of DNA primer strands.

A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...

What makes the human brain unique? A Yale study unlocks new insights into genetic changes that shaped our evolution.

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...