One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids -- key components of LNPs that change their charge to help them escape the endosome.

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids — key components of LNPs that change their charge to help them escape the endosome.

Autophagosome formation depends on the activity of a type III PI3K lipid kinase. Undefined vacuole-like ultrastructures between epididymal cells have been observed. Here, the authors reveal that ...

During endosome maturation Rab5 is replaced by Rab7 on endosomes that are able to fuse with lysosomes to form endolysosomes. However, whether ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are ...

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...

For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in ...

ULK1 complex initiates phagophore nucleation by phosphorylating components of the PI3KC3 complex that leads to the recruitment of several ATGs to assist autophagosome formation ... autophagy-related ...

7 International Research Fellow of Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan (Standard)), Tokyo, Japan Correspondence to Dr Shinji Saitoh, Department ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.biochem.4c00565.