During endosome maturation Rab5 is replaced by Rab7 on endosomes that are able to fuse with lysosomes to form endolysosomes. However, whether ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are ...

7 International Research Fellow of Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan (Standard)), Tokyo, Japan Correspondence to Dr Shinji Saitoh, Department ...

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.

Autophagosome formation occurs when mTOR and other signalling ... Common lysosomal inhibitors include Bafilomycin A1 (BafA1), chloroquine (CQ), and hydroxychloroquine (HCQ). A systematic review and ...

Alpha-synuclein (α-syn), a major component of Lewy bodies found in Parkinson’s disease (PD) patients, has been found exported outside of cells and may mediate its toxicity via cell-to-cell ...

ML-SA1 was able to override the effect of Bafilomycin A1, which blocks the fusion of the autophagosome and lysosome and its ... was achieved by incubation with 5 nM bafilomycin A1 (BafA1; Tocris ...

Immunofluorescence studies revealed that miR-29b replacements enhanced the bortezomib-induced accumulation of ubiquitinated proteins but did not reveal aggresome or autophagosome formation.