As the world's population ages, intervertebral disk degeneration (IDD) has become a major medical issue, causing chronic ...

A preclinical study finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity -- two issues that commonly co-occur with ...

HRP-linked anti-mouse IgG (7076S; Cell Signaling Technology) and HRP-linked anti-rabbit IgG (7074S, Cell Signaling Technology) were used as secondary antibodies. ECL substrate (Bio-Rad Diagnostic) was ...

ACh is produced by the enzyme choline acetyltransferase and its actions are mediated through two types of acetylcholine receptors (AChRs) — the G protein-coupled muscarinic AChRs and the ...

Clustering of type-II tumor necrosis factor receptors (TNFRs) is required to induce intracellular signaling. Current methods for receptor clustering lack precise control over ligand valency and ...

Northwestern Medicine investigators have discovered previously unknown metabolic changes that may contribute to the development of estrogen receptor ... cancer through an enzyme called ...

In this study, a research team from Dalhousie University, led by Sultan Darvesh, discovered that certain anti-aging compounds, known as senolytics, can block harmful brain enzymes linked to ...

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 , United States Department of Pharmacology, University of Colorado Anschutz ...

This study investigated the production of functional autoantibodies (fAABs) against the second loop of the G-protein-coupled receptor (GPCR) in the presence of hepatic and PAH forms of human SM.