But if the lower esophageal sphincter opens too often or does not ... causes damage to the esophagus in the form of esophagitis, ulcers, difficulty or pain when swallowing, strictures (narrowing ...

If the sphincter relaxes too much or becomes too ... it can cause small open sores called esophageal ulcers. Esophageal ulcers typically occur in the lining of the lower part of the esophagus ...

the formation of ulcers. Most cases of erosive esophagitis occur from repeated exposure to stomach acids in people with GERD. The lower esophageal sphincter is a muscular valve that normally ...

and has produced increased peristaltic and lower esophageal sphincter pressures in normal volunteers. Agrawal et al. evaluated the effect of bethanechol on smooth-muscle contraction in patients ...

In the present study, also signs were improved including lower esophageal sphincter (LES) pressure (from 10 ± 1.58 and, 10.3 ± 1.68 mmHg in the pretreated patients to 16.5 ± 0.6, and 14.1 ± 0. ...