RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Then the RNA binding protein communicates to the splicing machinery ... Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often ...

Unlike the nuclear genome, most eukaryotes pack their circular mtDNA into nucleoids ... You could conceivably retrieve all of your barcode sequences in a single NGS run,” said Liu. RNA sequencing (RNA ...

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have ...

Eukaryotic genomes contain a variety of structured patterns ... become able to bind DNA and activate gene transcription by interacting with the RNA polymerase machinery (Farnham, 2009). Analysis of ...

We have performed ChIP-seq experiments on tightly staged Drosophila embryos and show that massive recruitment of RNA polymerase II (Pol II) with widespread pausing occurs de novo during the ...