because immortalized glomerular human endothelial cells did not respond to insulin. In podocytes, as in muscle and adipocytes, GLUT4 translocation is dependent on an intact actin cytoskeleton to ...

Injury of podocytes, if recognized at all ... TGF-β1 causes an increase in mesangial matrix deposition and glomerular basement membrane (GBM) thickening and may promote podocyte apoptosis ...

Walden’s programs address novel targets for therapeutic intervention, directly targeting two cell types critical for kidney function: podocytes and proximal tubular cells. Dysfunction of these ...

Clinical features include macroalbuminuria and a reduction in glomerular filtration rate ... report that ceramide synthase 6 (CerS6) in podocytes contributes to the pathogenesis of diabetic ...

demonstrating its ability to deliver genes to podocytes, specialised epithelial cells in the kidney that are involved in regulating glomerular filtration. The round was led by Sofinnova Partners ...

Puromycin aminonucleoside (PAN) induced segment-specific injury in glomerular podocytes in kidney organoids in the absence of tubular injury. Reporter organoids were generated with an ATP/ADP ...

Podocytes are crucial due to their dual barrier functions ... glomerulosclerosis, Poria cocos, glomerular diseases, fibroblasts, connective tissue growth factor, coagulation, and Wnt. Recent research ...

aCenter for Renal Translational Medicine/Institute for Metabolomic Medicine, University of California San Diego, San Diego, CA, United States bDepartment of Clinical and Molecular Medicine, Faculty of ...