A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

The study reveals how ER-stressed adipocytes remotely regulate UPR activation in hepatocytes through the secretion of ceramide (Cer), a fat molecule that plays a major role in cell structure, ...

In the study, the researchers first confirmed that ER-stressed adipocytes secrete bioactive signaling molecules capable of activating the UPR pathway in hepatocytes across tissues. Using ...