Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and ...

TET2 works with HNF4α to activate the FBP1 gene upon glucagon stimulation, while metformin disrupts TET2-HNF4α interaction, lowering FBP1 levels and improving glucose homeostasis. The results are ...

Yale Cardiovascular Research Center CT, Yale University School of Medicine, New Haven, CT.(H.D., A.E., M.A.S.) Section of Cardiovascular Medicine, Department of ...

Background Injured or reactive biliary epithelial cells participate in most chronic liver injuries in a process referred to as ductular reaction, which involves multicellular interactions with marked ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...

The 2025 Breakthrough Prize in Life Sciences has been awarded to five scientists for the discovery and characterization of the hormone glucagon-like peptide-1, or GLP-1 — findings that subsequently ...

pennmedicine.upenn.edu Background/aims Glucagon-like peptide-1 receptor (GLP-1R) agonists regulate blood glucose and are commonly used to treat type 2 diabetes mellitus. Recent work showed that ...

In the study, the researchers first confirmed that ER-stressed adipocytes secrete bioactive signaling molecules capable of activating the UPR pathway in hepatocytes across tissues. Using ...

The study reveals how ER-stressed adipocytes remotely regulate UPR activation in hepatocytes through the secretion of ceramide (Cer), a fat molecule that plays a major role in cell structure, ...