AMPA receptors recycle in the postsynaptic membrane ... would be activated synchronously by glutamate release from the same terminal? Is this a stable endpoint of synaptic plasticity, or are ...
AMPA receptors, ligand-gated ion channels that mediate fast, excitatory synaptic transmissions, are activated by glutamate, the primary neurotransmitter of the mammalian brain. Surprisingly ...
In a study published in Cell, a research team led by Zhu Shujia from the Center for Excellence in Brain Science and ...
Pathologically high levels of extracellular glutamate can cause excitotoxicity, when postsynaptic receptors such as NMDA and AMPA are overactivated, allowing high levels of calcium influx that trigger ...
So far, we have identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Our current research aims to understand ...
while co-exposure of TNF-α and for example AMPA may have neuroprotective effects compared to cultures exposed to excitotoxic agents alone. In addition our work has shown that although glutamate ...
Perampanel is a non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. Glutamate is the primary ...