A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...
Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...
As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...
VANCOUVER, Washington, Feb. 06, 2025 (GLOBE NEWSWIRE) -- (OTCQB: CYDY) ("CytoDyn" or the "Company"), a biotechnology company ...
Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, ...
Activated hepatic stellate cells (HSCs) produce mass of extracellular matrix (ECM), which could result in liver fibrosis (Higashi et al., 2017). Moreover, tissue inhibitor of metalloproteinases (TIMPs ...
jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...
Hepatic macrophages can interact with hepatocytes, hepatic stellate cells, and endothelial cells, playing a crucial role in maintaining homeostasis. Paradoxically, they also participate in the ...
A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...
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