Till Strowig (New York) showed that EBV-infected NOG mice transgenic for human HLA-A2 and transplanted with HLA-A2 + human HSCs can mount protective EBV-specific T cell responses that limit B cell ...

These mice expressed the human leukocyte antigen (HLA) allele (DRB1*15:01) instead of the mouse version of the same allele, which codes for the proteins that display foreign antigens on the surfaces ...

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with ...

A new study shows that giving mice the human version of a gene changes their squeak, suggesting some of the genetic ...

and in mice with the human genes for HLA-DQ2.5. They then created functional living models of the gut, called an organoid, using the mouse intestinal cells in order to study the expression of ...

Figure 1: Insulitis in humans and NOD mouse pancreas. Although they are important ... might predispose children with autoimmune-permissive HLA haplotypes to higher risk for eventual penetrance ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

“Our paper demonstrates that they exhibit human-like telomeres. Now, we aim to observe how these mice age.” The team’s study Modification of the telomerase gene with human regulatory ...