Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Gene therapies to treat rheumatoid arthritis have evolved slowly, but one is ready to move into human trials and an osteoarthritis treatment in human trials may have potential for treating RA.

At that other end is an immunological surveillance system that in humans is called the human leukocyte antigen (HLA) complex ... promising results were seen in mice 9. ProFound Therapeutics ...

The temporal evolution of macrophage MerTK expression and its impact on resolution was examined in APAP-induced acute liver injury using wild-type (WT) and Mer-deficient (Mer −/−) mice. SLPI effects .

used the mouse model to identify the ... can be further employed in the human placenta during the first, second and third trimester, which facilitates the understanding of dynamic changes of KIRs and ...

Hence, understanding how minor alleles (ie, non-HLA-B27) and non-genetic factors such as environmental triggers collaboratively shape disease would be of considerable interest and importance to human ...

A new study shows that giving mice the human version of a gene changes their squeak, suggesting some of the genetic ...

A new study shows that giving mice the human version of a gene changes their squeak, suggesting some of the genetic underpinnings of language.

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with ...

With more than 100,000 Americans waiting on a new organ, xenotransplantation is a leading example of how editing animals ...

“Our paper demonstrates that they exhibit human-like telomeres. Now, we aim to observe how these mice age.” The team’s study Modification of the telomerase gene with human regulatory ...