This webinar will explore the most recent ASO chemical modification: locked nucleic acid (LNA), which confers high potency. Our expert speakers will provide insights into the critical in vitro and in ...

Plants know how to defend themselves against pathogenic microorganisms. In turn, pathogens have sensors to detect such ...

It will slot into Roche’s pipeline of HBV candidates, with five early-stage clinical candidates including liver-targeted locked nucleic acid oligonucleotide RG6004, oral TLR7 agonist RG7854 and ...

Nucleic acids are named for where they're found—inside ... like Lego bricks, or a lock and key. By the late 1800s, surgeons ...

Biotechnological Tools: Creation of innovative biotechnological applications such as aptamers and synthetically modified oligonucleotides (e.g., peptide nucleic acids [PNA], locked nucleic acids [LNA] ...

Alongside proteins, carbohydrates, and nucleic acids, fatty acids help build and maintain living ... what traces of it remain locked beneath the planet’s surface?

In this study, we tested if locked nucleic acid (LNA) miR-181a-5p antisense oligonucleotides (ASO) could be used as a therapeutic to limit articular cartilage degeneration. Methods We used a variety ...

An inhibitor of miR-34a (locked nucleic acid, LNA-34a) exerted antiproliferative activity in primary cultures of hepatocyte. This inhibition of proliferation was associated with a decrease in cyclin ...

Additionally, lncRNAs, such as Neat1 and locked nucleic acid, have been implicated in stabilizing rhythmic gene expression by interacting with chromatin modifiers and transcriptional regulators. These ...