G protein-coupled receptors ... that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling. To help in the rational ...

The cascades involve Ca 2+ sensors, protein–protein interactions ... activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs).

Seeking students to join a new and growing lab that seeks to understand the molecular causes of cancer in order to develop better therapies and improve patient outcomes. Our lab seeks to understand ...

The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...

Drug promiscuity can also be evaluated from the reverse perspective, focusing instead on the ability of a single therapeutic agent to interact with multiple protein targets. The most comprehensive ...

The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR. While the active structure of the C3a-C3aR-G i complex has been determined, the ...

For example, uncooked brown rice provides 25.8 grams (g) in a 100-g serving. This type of rice is higher in protein than some other types of rice. A 100-g portion also contains 123 calories.

However, the contribution of intracellular Aβ or other cleavage products of its precursor protein (APP) to synaptic loss remains uncertain. In this study, we conducted a systematic examination of ...

In this study, we developed and optimized a bioconjugation strategy to fuse recombinant proteins resembling collagen and elastin using the SpyTag/SpyCatcher system. The proteins were successfully ...