Compared with placebo, xanomeline/trospium as an add-on to atypical antipsychotics has not reached the threshold for a ...

New Delhi: The pharmaceutical major Cipla has got the go-ahead from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organization (CDSCO) for conducting Phase III ...

At Lilly, Paul helped develop the company’s mental health blockbusters, Zyprexa and Cymbalta, and helped oversee development of muscarinic cholinergic receptor agonist xanomeline, where its ...

The US regulator has cleared the combination of muscarinic M1 and M4 ... entirely on drugs that block dopamine receptors, so Cobenfy's action on cholinergic receptors offers a brand new way ...

These findings are consistent with previous studies showing that cholinergic compounds like arecoline can alter hippocampal function by activating muscarinic and nicotinic acetylcholine receptors ...

According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million ...

TNX-102 SL is a potent antagonist at four post-synaptic receptors, each of which is involved in regulating sleep. TNX-102 SL is designed for rapid, transmucosal absorption and, as demonstrated in ...

which “could increase SD risk by blocking peripheral adrenergic and cholinergic receptors and increasing sympathetic activity.” Dermatologists, they added, “may consider a neurology ...

The primary goal of the trial is to measure the decrease in the Positive and Negative Syndrome Scale from baseline.

The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR. While the active structure of the C3a-C3aR-G i complex has been determined, the ...