In FIRE mice, the lack of microglia causes myelin overgrowth and eventual degeneration, indicating that microglia may contribute to age-related neurodegenerative diseases. Since aging perturbs myelin ...

The most severe injuries have been associated with widespread axonal and myelin degeneration (Gentili, Hudson, and Hunter, 1980a). Pathological alterations in the nerve were evident as early as 30 ...

Myelin is an insulating layer of lipids and proteins surrounding nerves. Myelin damage can cause problems with the nerves’ ability to send and receive electrical messages. Inflammatory disorders ...

Myelin is a concentrically laminated membrane ... leaving axons and even the entire neuron vulnerable to degeneration. Thus, patients with demyelinating diseases suffer from various neurological ...

Demyelination refers to damage to the myelin around nerves. Myelin coats many nerves in the body, but it can become damaged due to inflammation from viral infections, autoimmune diseases ...

Myelin degeneration can result in scarring, or lesions on the nerves, most commonly in the brain and spinal cord, which in ...

The drug, LL-341070, enhances the brain's ability to repair damaged myelin— the protective sheath around nerve fibers. Damage to myelin is a hallmark of diseases like MS, as well as a natural ...

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene "silencer" that resides in junk DNA is directly sparing people from a devastating ...

Activated microglia can mediate the tissue injury through secretion of toxic cytokines, complement proteins, and free radicals that can lead to the degeneration of myelin, axonal dysfunction ...