Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
Hu, C. Yau and A. Ahmed (2017 ... While some mutations can introduce premature termination codons (PTCs) into genes, nonsense mediated decay (NMD) can detect these PTCs and then eliminate the abnormal ...
The past number of days have brought unprecedented challenges as Storm Éowyn swept through Co Armagh, leaving a profound impact on communities and a trail of destruction and disruption. As a result, ...