A 69-year-old woman presented with a large, deep area of skin necrosis on the right breast. One month earlier, the patient had undergone a surgical treatment for a frontal-parietal meningioma.

A 17-year-old white male with Crohn's disease who was receiving maintenance infusions of the anti-tumor necrosis factor (TNF) agent, infliximab, presented with a new-onset psoriasiform skin rash.

Long-term TNFi use in patients with psoriasis was not associated with a higher risk of cancer, including lymphoma, prostate cancer, and breast cancer.

WINS must be differentiated from all other causes of acute thrombosis with skin necrosis, including acute necrotizing fascitis, disseminated intravascular coagulopathy with purpura fulminans ...