p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and ...

In more than half of all human cancers, p53 is either missing or dysfunctional. This often happens when the gene that encodes for p53 is mutated or deleted. Without a functioning p53, errors in ...

When the TP53 gene was disrupted in these cells, they grew faster and became more resistant to radiation, reinforcing the idea that p53 helps prevent cancerous growth. Another key discovery was a ...

When the TP53 gene was disrupted in these cells, they grew faster and became more resistant to radiation, reinforcing the idea that p53 helps prevent cancerous growth. Another key discovery was a ...

Researchers are investigating whether a common cholesterol drug could be repurposed to treat HPV-positive cervical cancer.

Mutations in the TP53 gene occur in approximately half of human cancer types ... described the effect of rezatapopt (PC-14586), a first-in-class selective p53 reactivator designed to reinstate p53 ...