Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

USPs such as USP22 and USP7 regulate key proteins like c-Myc and p53, influencing apoptosis in BC. Similarly, autophagy, a mechanism for cellular self-digestion, has a paradoxical role in BC ...

(2) Does Kras mutation and/or p53 loss upregulate Msi2 ... we have recently published data showing that the stabilization of the oncogenic MYC protein in lung Msi2+ cells drive the formation of ...