Medscape4d
Lung Cancer Pathogenesis Associated With Wood Smoke Exposure
The increase in MDM2 could be due to a high phosphorylation of the p53 N-terminal domain that prevents the formation of MDM2-p53 complexes with an accumulation of both molecules. Moreover ...
Nature13d
Absence of cancer–associated changes in human fibroblasts immortalized with telomerase
Figure 2: The retinoblastoma protein phosphorylation status in normal and telomerase–expressing fibroblasts. Figure 3: Effects of UV irradiation on the expression of p53 and p21 Cip1/Waf1 ...
Cancer Research12d
HPV and p53 Status as Precision Determinants of Head and Neck Cancer Response to DNA-PKcs Inhibition in Combination with Irradiation
1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...
Frontiers13d
It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic stresses, are our bodies’ greatest weapons to battle against cancer onset and development. Consequently, factors that ...
eLife4d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
gut.bmj13d
p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus
Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...
eLife4d
Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9
In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...
Frontiers13d
Why is Mortalin a Potential Therapeutic Target for Cancer?
It is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of ...
gut.bmj11d
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
coli-induced senescence and tumour growth. The mechanism underlying colibactin-induced senescence involves microRNA-20a-5p, which targets SENP1, a key protein in the regulation of p53 SUMOylation. The ...
Scientific Research Publishing3d
Molecular Mechanisms of the CIRBP Family in Tumors: Current Status and Future Perspectives ()
CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...
verywellhealth26d
The TP53 Gene and Its Role in Cancer
The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...