Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

cGAS can also act as a selective autophagy receptor for micronuclei causing their ultimate degradation and thereby prohibiting them from releasing DNA into the cytosol. Finally, K48-linked ...

Furthermore, PHSML incubation inhibits cellular contractile response and induces autophagy of VSMCs with evidence of increased expressions of LC3-II/LC3-I and Beclin 1 and decreased expression of p62, ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

As the reviewer pointed out, changes in the LC3-II/LC3-I ratio do not necessarily indicate autophagy defects. However, since p62 accumulation (Figure 2B, 2E, 3E, 6C, 7C in the original manuscript), ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D (CTSD ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule ... while increasing the level of p62. Meanwhile, DF-O and MPs samples induced apoptosis through increasing ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...