Dr. Marwan G. Fakih explains that KRAS mutations, found in 45% of patients with colorectal cancer, include the rare KRAS G12C mutation, leading to Lumakras approval.

Chloe Wakelin, a nursery worker and mom-of-one from Rochdale, said she had sought help from medics for months for help with symptoms but was repeatedly brushed off.

Who should file a tax return, how to get ready for taxes, filing and payment due dates, reporting your income and claiming deductions, and how to make a payment or check the status of your refund.