How a multitasking protein keeps the body's clock in sync
If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...
Human genetics provides clues to why DNA regulatory regions get 'loopy'
DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...
AZoLifeSciences on MSN2d
How Proteins Are Made: From DNA to Function
Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...
Too Old to Operate6d
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been ...
Science Daily27d
New mechanism for maintaining genome stability discovered
The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP ... interacted with RNAP -- but with no obvious function. "At the time, we really couldn't figure out what ...
eLife5d
HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity
Abstract Research of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM), two acquired chronic illnesses affecting mainly females, has failed to ascertain their frequent ...
Frontiers7d
RNA-seq analysis-based study on the effects of gestational diabetes mellitus on macrosomia
Background: Both the mother and the infant are negatively impacted by macrosomia. Macrosomia is three times as common in hyperglycemic mothers as in normal mothers. This study sought to determine why ...
The EMBO Journal9d
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...