RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Genomics has provided an inventory of the catalytic subunits of human protein phosphatases ... Ssu72 control the phosphorylation state of RNA polymerase II CTD in the nucleus.

Researchers discover a new subunit of a bacterial RNA polymerase—as well as hints of its potential ... of the mystery protein revealed that it was not related to known subunits and therefore deserved ...

Introduction: RNA polymerase III (Pol III) is a critical enzymatic complex ... hypomorphic biallelic pathogenic variants in genes encoding subunits of Pol III lead to tissue-specific features and ...

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have ...

We have performed ChIP-seq experiments on tightly staged Drosophila embryos and show that massive recruitment of RNA polymerase II (Pol II) with widespread pausing occurs de novo during the ...