The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system.

These insights from researchers could have major implications for diseases like cancer, where gene expression goes awry.

Scientists at the Icahn School of Medicine at Mount Sinai have made an exciting discovery about how human cells make RNA, a molecule that carries important instructions inside our bodies.

As a transcriptional cofactor, AID interacts with RNA Polymerase II and SPT5 to influence transcription elongation. While its highly charged structure allows nonspecific protein binding, functional ...