RNA polymerase is an enzyme that is responsible ... there are striking similarities among transcriptional mechanisms. For example, all species require a mechanism by which transcription can ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP ... so cells have many redundant mechanisms to prevent them from forming," says Seth Darst, head of the ...

and viral polymerases • Relate polymerase structure to enzymatic mechanism • Define how polymerases and terminal transferases achieve specificity for distinct substrates: incorporation of dNTP or rNTP ...

If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...

A global team has made a significant advance in understanding how bacterial plasmids contribute to antibiotic resistance.

Trends Biochem Sci 2022, 47: 314 - 327. Palacio, M; Taatjes DJ. Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription. J Mol Biol ...

The Taatjes lab investigates the molecular mechanisms by which the human transcription machinery functions and is regulated. Proper regulation of gene expression is fundamental to every major ...

EZH1 is a key regulator of circadian rhythms, stabilizing gene transcription and modifying chromatin to maintain genetic ...