RNA polymerase is an enzyme that is responsible ... there are striking similarities among transcriptional mechanisms. For example, all species require a mechanism by which transcription can ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP ... so cells have many redundant mechanisms to prevent them from forming," says Seth Darst, head of the ...

If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...

A global team has made a significant advance in understanding how bacterial plasmids contribute to antibiotic resistance.

Trends Biochem Sci 2022, 47: 314 - 327. Palacio, M; Taatjes DJ. Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription. J Mol Biol ...

The Taatjes lab investigates the molecular mechanisms by which the human transcription machinery functions and is regulated. Proper regulation of gene expression is fundamental to every major ...

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...