RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Discovering transcription factor (TF) targets is necessary for the study of regulatory ... leaf cells based on 10 × Genomics’ single-cell RNA sequencing method. We effectively utilized the transient ...

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have ...

Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete ... indicating that FMRP is a ZIKV restriction factor. We further observed that an attenuated ZIKV strain compromised ...

We have performed ChIP-seq experiments on tightly staged Drosophila embryos and show that massive recruitment of RNA polymerase II (Pol II) with widespread pausing occurs de novo during the ...