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Janus kinase inhibitor cycling may be more effective than switching to bDMARDs among patients with RA who had an inadequate response to initial JAK inhibitor therapy.

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Filgotinib maintained a favorable safety and efficacy profile for up to 8 years among patients with RA who participated in the DARWIN 3 LTE.

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Moreover, the DAS-28-CRP score can be elevated in patients with either persistent inflammatory RA (PIRRA) or non-inflammatory RA (NIRRA), where the latter do not benefit from medication change [2].