The pre-B-cell receptor (pre-BCR), which comprises two ... Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

January 2025 kicked off with a wave of impactful biotech deals, setting the stage for an exciting year of innovation.

D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...

Indeed, the cAMP/type I PKA/Csk/Lck [lymphocyte-specific protein tyrosine kinase (PTK)] signaling module has ... Besides the Gs/AC/cAMP pathway, active EP2 and EP4 receptors trigger multiple signaling ...

HER2 signaling pathway. Receptor homodimerization or heterodimerization is ... to trigger HER2 internalization and degradation through promoting the activity of tyrosine kinase – ubiquitin ligase ...

binds to the receptor tyrosine kinase c-Met and is a multifunctional cytokine that promotes processes such as cell proliferation, survival, differentiation, migration and angiogenesis [1]. We ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

Data from the Phase 3 PALOMA-3 study showed non-inferiority to intravenous administration meeting both co-primary pharmacokinetic (PK) endpoints, as well as a five-fold reduction in infusion-related ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

such as increasing the function of oestrogen receptor-α and E2F1, the activity of the insulin-like growth factor 1 (IGF1) signalling pathway, epidermal growth factor receptor (EGFR) and ERBB2 ...