Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...

Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA ...

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

A novel, freely available AI tool has cut the time it takes to determine chromatin structure from days to minutes. The 3D ...

A study reveals DNA and RNA epigenetics work together as a complementary system for precise gene regulation, crucial for cell ...

This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

Biologically active RNAs, including transport, ribosomal and small nuclear RNA (tRNA, rRNA, snRNAs) fold into unique structures guided by complementary pairing between nucleotide bases.

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

an RNA structure normalization tool used in RNA-Puzzles. the RNA 3D structure comparison metrics used in RNA-Puzzles assessment, including RMSD (all-atom), P value, Interaction Network Fidelity and ...