Now, researchers used cryoelectron microscopy (cryo-EM) to elucidate the structure of the Nipah virus polymerase complex ... for both transcription and RNA replication and mutations that have ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

Here, the knowledge relating to miRNAs’ relationships between host miRNAs and RNA viruses are discussed. Figure 1 The process of miRNA formation. The miRNA genes are transcribed for pri-miRNA by ...

Recent cryo-electron microscopy (cryo-EM) and tomography data, also combined with crosslinking-mass spectrometry experiments, have uncovered detailed structural features of the coupling between a ...

To cap the RNA product, m7G(5’)ppp(5’)G RNA Cap Structure Analog (New England Biolabs ... 10 μg of the purified RNA was then polyadenylated by 4U poly(A) polymerase (New England Biolabs) at 37°C for 1 ...

Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA. Researchers ...

Enzymes made of RNA are called "ribozymes." A group of researchers led by Professor Claudia Höbartner at the University of Würburg (JMU) has now uncovered the three-dimensional structure of a ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.